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How Cinnemaldehyde Inhibits Microbes

STAPHYLOCOCCI

• Inhibits Cell Division by inhibiting FTSP-Z (filamentation temperature-sensitive protein Z)
• Destroys the Gram-positive cell wall – causes leakage of cytoplasmic contents
• Inhibits Staph. enzymes that convert host proteins into nutrients

PSEUDOMONAS

• Disrupts Biofilm matrix production at very low concentrations
• Rapid destruction of the cell membrane in multidrug-resistant organisms
• Inhibits efflux pumps to allow antibiotics to concentrate in the cytoplasm

MALASSESIA

• Inhibits ergosterol synthesis, so weakens the cell membrane, leading to leakage of cytoplasmic contents
• Inhibits the production of the thick outer cell wall Beta-glucans
• Causes mitochondrial damage, leading to apoptosis

CinnaZoo Reference Articles with Summaries

Antibacterial – Staphylococcus (Including MRSP, Skin/Ear Infections)
Cinnamaldehyde and Staphylococcal Infections
Cinnamaldehyde against MRSP pyoderma
Cinnamaldehyde in resistant canine Staph otitis dogs

Antibacterial – Pseudomonas (Including Resistance And Virulence)
cinnamaldehyde – multi-drug resistant Pseudomonas
Cinnamaldehyde and Pseudomonas Virulence
Cinnamaldehyde virulence Pseudomonas

Antibacterial – Oral / Anaerobes / Other Bacteria
cinnamaldehyde and Porphyromonas
Cinnamaldehyde and oral infections in people

Broad-Spectrum Antibacterial / Antibiotic Synergy
Cinnamaldehyde In Combination With Antibiotics.pdf
Cinnamaldehyde With Antibiotics In G+ And G- Bacteria.pdf
Cinnamaldehyde and Synergy with Chlorhexidine
Antimicrobial Effects of Cinnamon Essential Oil.pdf

Antifungal – General And Synergy
Antifungal Activity Of The Essential Oils Of Eight Cinnamomum Species.pdf
Cinnamaldehyde And Antifungal Synergism.pdf

Antifungal – Specific Organisms (Dermatophytes, Malassezia)
Cinnamaldehyde and Dermatophytes
Cinnamaldehyde and Microsporum and Trichophyton
Cinnamaldehyde And Malassezia.pdf
Cinnamaldehyde and Malassezia Sensitivity

Mechanism Of Action / Cellular Effects
Cinnamaldehyde and EDTA Effective Against Biofilms
Cinnamaldehyde Mechanism Of Action.pdf
Cinnamaldehyde And Biofilm.pdf
Cinnamaldehyde And Macrophages.pdf
Cinnamaldehyde And Pseudomonas Virulence.pdf

Toxicity / Safety / Host Response
Cinnamaldehyde And Toxicity To Keratinocytes.pdf
Cinnamaldehyde And Transient Edema.pdf
Cinnamaldehyde Anti-Inflammatory Effects In Mice With AD.pdf

Wound Healing / Dermatologic Application
Cinnamaldehyde In Wounds.pdf
Cinnamaldehyde Topically Promotes Faster Wound Healing.pdf
TC Dermal Absorption

Formulation / Product Development / Patents
Cinnaderm Related Patent

Extraction / Chemistry / Processing
Cinnamaldehyde Extraction From Bark.pdf
Purification Of Cinnamaldehyde From Cinnamomum Zeylanicum Bark Oil.pdf
Cinnamaldehyde Steam Distillation.pdf
Cinnamon Essential Oil.pdf

Combination Therapies / Immunologic Modulation
Cinnamaldehyde Can Reduce Inflammation by Dr. Louis Gotthelf
Cinnamaldehyde and Dexamethasone Combination
TC is a Toll Like Receptor 4 Blocker

Miscellaneous / Other Applications
Cinnamaldehyde As A Mosquito Repellent.pdf
Cinnamaldehyde In Milk.pdf